Table 1 Demographic and clinical characteristic at baseline
|  | IAI/CE + PREP | IAI/Saline + PREP | IAI/Placebo + PREP |  |
|---|---|---|---|---|
(n = 15) | (n = 15) | (n = 15) | p | |
Gender (Women) | 14 (93.3%) | 13 (86.7%) | 11 (73.3%) | 0.463 |
Age (years) | 70.5 ± 5.5 | 71.3 ± 5.6 | 71.9 ± 7.4 | 0.828 |
Education (years) | 6.7 ± 3.4 | 6.7 ± 3.1 | 7.7 ± 3.2 | 0.627 |
Disease duration (years) | 5.6 ± 2.4 | 6.1 ± 2.5 | 5.2 ± 1.8 | 0.467 |
BMI (kg/m2) | 30.95 ± 5.42 | 29.31 ± 3.89 | 29.31 ± 4.61 | 0.548 |
Ethnicity (white) | 9 (60.0%) | 12 (80.0%) | 13 (86.7%) | 0.204 |
Marital status (maried) | 9 (60.0%) | 10 (66.7%) | 9 (60.0%) | 0.667 |
Caidor crônico | 4 (26.7%) | 2 (13.3%) | 2 (13.3%) | 0.697 |
Diseases | Â | Â | Â | Â |
 Hypertension | 10 (66.7%) | 10 (66.7%) | 12 (80.0%) | 0.77 |
 Diabetes Mellitus | 8 (53.3%) | 8 (53.3%) | 4 (26.7%) | 0.274 |
 Dislipidemia | 8 (53.3%) | 10 (66.7%) | 7 (46.7%) | 0.651 |
 Others | 7 (17.5%) | 8 (20.0%) | 6 (15.0%) | 0.841 |
Medications | Â | Â | Â | Â |
 Hypertension | 10 (66.7%) | 10 (66.7%) | 12 (80.0%) | 0.77 |
 Diabetes Mellitus | 8 (53.3%) | 9 (60.0%) | 4 (26.7%) | 0.176 |
 Dislipidemia | 8 (53.3%) | 10 (66.7%) | 7 (46.7%) | 0.651 |
 Oral analgesics | 4 (26.7%) | 5 (33.3%) | 4 (26.7%) | 1 |
 NSAIDs | 0 (0.0%) | 0 (0.0%) | 1 (6.7%) | 1 |
 Cartilage supplement | 0 (0.0%) | 0 (0.0%) | 2 (13.3%) | 0.318 |
 Others | 7 (46.7%) | 7 (46.7%) | 7 (46.7%) | 0.318 |
Kellgren Lawrence grade | Â | Â | Â | Â |
 II | 8 (53.3%) | 6 (40.0%) | 8 (53.3%) | 0.806 |
 III | 7 (46.7%) | 9 (60.0%) | 7 (46.7%) | 0.806 |
Involvement | Â | Â | Â | Â |
 Unilateral | 5 (33.3%) | 7 (46.7%) | 3 (20.0%) | 0.361 |
 Bilateral | 10 (66.7%) | 8 (53.3%) | 12 (80.0%) | 0.361 |