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Table 5 Incidence rate ratio (IRR) of TBD in IMID patients being treated with the different classes of DMARDs

From: Brazilian recommendations for the management of tuberculosis infection in immune-mediated inflammatory diseases

DMARD

Incidence/100,000 py

IRR

p-value

tsDMARDs

234

Comparator

Comparator

csDMARDs

392

1.6748

< 0.00001

All TNFi

844

3.6056

< 0.00001

Etanercept

390

1.6672

< 0.0001

Adalimumab

948

4.0488

< 0.0001

Infliximab

981

4.1910

< 0.0001

Certolizumab pegol

193

0.8248

0.0474

Golimumab

532

2.2752

< 0.0001

Non-TNFi bDMARDs

379

1.6198

< 0.0001

Tocilizumab

320

1.3690

0.0003

Rituximab

720

3.0783

< 0.0001

Abatacept

351

1.4977

< 0.0001