Skip to main content
Fig. 2 | Advances in Rheumatology

Fig. 2

From: Endoplasmic reticulum stress in the salivary glands of patients with primary and associated Sjögren’s disease, and non-Sjögren’s sicca syndrome: a comparative analysis and the influence of chloroquine

Fig. 2

Distribution of ERS genes among the four groups (pSD, aSD, NSS, and HC). Legend 2 The expression of BIP is notably higher in the pSD group compared to other groups, and it is undetectable in the HC group. PERK exhibits significant upregulation in both pSD and aSD groups compared to the NSS and HC groups. In contrast, ATF-6 was downregulated in the pSD, aSD, and NSS groups compared to the HC group. There was no significant difference in ATF-4 expression between groups. CHOP expression was lower among patients than healthy controls, mainly in the aSD group. There was an overexpression of XBP1 in both pSD and aSD groups compared to the HC group. CALR expression was significantly lower in the NSS group. Finally, CANX expression was significantly higher in the SD groups (pSD and aSD) compared to the NSS and HC groups

Back to article page

Advances in Rheumatology

ISSN: 2523-3106