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Fig. 3 | Advances in Rheumatology

Fig. 3

From: Hck promotes IL-1β-induced extracellular matrix degradation, inflammation, and apoptosis in osteoarthritis via activation of the JAK-STAT3 signaling pathway

Fig. 3

Hck enhances IL-1β-induced ECM degradation, inflammation, and apoptosis in chondrocytes via JAK-STAT3 signaling pathway. A Western blot analysis of JAK-STAT3 signaling proteins in IL-1β-stimulated chondrocytes following Hck knockdown and colivelin treatment. B CCK-8 assay measuring cell viability in IL-1β-stimulated chondrocytes following Hck knockdown and colivelin treatment. C-D ELISA examined the levels of inflammatory markers in IL-1β-stimulated chondrocytes following Hck knockdown and colivelin treatment. E Cell apoptosis in IL-1β-stimulated chondrocytes following Hck knockdown and colivelin treatment was measured by flow cytometry. F-G Western blot analyzed the levels of apoptosis and ECM-related proteins in IL-1β-stimulated chondrocytes following Hck knockdown and colivelin treatment. P < 0.01, vs. control group. ##P < 0.01, vs. IL-1β group. &&P < 0.01, vs. IL-1β-si-Hck#2 group

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Advances in Rheumatology

ISSN: 2523-3106