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Table 1 Short- and long-term adverse events related to cyclophosphamide therapy [1]

From: Position statement of the Brazilian society of Rheumatology on mesna use as a preventive therapy for bladder disease in patients with systemic autoimmune diseases and systemic vasculitis under cyclophosphamide treatment

Toxicity

Description

Short-Term toxicity

 

Nausea/vomiting

 

Leucopenia/neutropenia

 

Bacterial infections

 

Opportunistic infections

 

Viral infections

 

Anaphylaxis

 

Hepatotoxicity

Long-Term toxicity

 

Gonadal toxicity/infertility

 

Teratogenicity

 

Hemorrhagic cystitis

 

Bladder cancer/Skin cancer/Leukemia

 

Interstitial lung disease

 

Alopecia

 

Cardiac toxicity