Fig. 5
From: SIRT1 is transcriptionally repressed by YY1 and suppresses ferroptosis in rheumatoid arthritis
YY1 promoted LPS-induced ferroptosis of synoviocytes through transcriptional inhibition of SIRT1. Synoviocytes were transfected with pcDNA-3.1, pcDNA-SIRT1 or pcDNA-YY1. A Cell viability was assessed by CCK-8 assay. B ROS production was detected by DCFH-DA fluorescent probe. C Iron level in the synoviocytes was examined by iron assay kit. Experiments were carried out in triplicate, mean ± SD, ***p < 0.001